| Autor: |
Selcuk, NA, Onsel, C, Ozturk, S, Gurmen, T, Gulbaran, M, Sager, S, Uslu, I |
| Přispěvatelé: |
Selcuk, NA, Onsel, C, Ozturk, S, Gurmen, T, Gulbaran, M, Sager, S, Uslu, I, Yeditepe Üniversitesi |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
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| Popis: |
Objective The aim of this study was to evaluate the feasibility and safety of intravascular radiation therapy (IVRT) using Re-188 filled balloon system in patients with in-stent stenosis. Methods A total of 39 patients with in-stent restenosis were enrolled as the IVRT (22 patients) and control groups (17 patients) of this study after a successful coronary angioplasty. For irradiation the angioplasty balloon was replaced by a noncompliant balloon of the same diameter but 10mm longer in length with a proximal and distal radio-opaque marker to deliver the dose of 18 Gy at 0.5mm depth from the surface of the balloon into the vessel wall. Angiographic follow-up was performed after 6 months. Results The length of the irradiated segment was between 9.14 and 22mm and the diameter between 2.5 and 3 mm. In the IVRT group, two patients who did not receive antiplatelet therapy had myocardial infarction. Four patients who presented with stable angina earlier also had angiographically documented in-stent occlusion (two patients) and edge stenosis (two patients) of the target lesion and received angioplasty (18.1%). In the control group, three patients with recurrent angina and four asymptomatic patients had documented in-stent occlusion angiographically at 6 months and these seven patients underwent target lesion revascularization (41.2%). The overall restenosis rate in the IVRT and control groups were 23.91 and 39.86%, respectively (P=0.013). No complications were documented, except anginal pain and ST segment changes. Conclusion Our results indicated that the Re-188 liquid-filled balloon is feasible, safe, and effective in patients with in-stent restenosis. Nucl Med Commun 31:746-752 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. International Atomic Energy AgencyInternational Atomic Energy Agency The authors appreciate the support of International Atomic Energy Agency and would like to thank Professor Dr Muzaffer Degertekin for his critical review of this manuscript. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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