Structure-function of cytochromes P450 and flavin-containing monooxygenases - Implications for drug metabolism

Autor: Halpert, JR, Domanski, TL, Adalı, Orhan, Biagini, CP, Cosme, J, Dierks, EA, Johnson, EF, Jones, JP, de Montellano, PO, Philpot, RM, Sibbesen, O, Wyatt, WK, Zheng, ZP
Přispěvatelé: OpenMETU
Rok vydání: 1998
Předmět:
Popis: This article is a report on a symposium held at Experimental Biology '98 in San Francisco, California. Recent developments in site-directed mutagenesis, computer-modeling, and mechanistic analysis of cytochromes P450 and flavin-containing monooxygenases are described. A unifying theme is the elaboration of general approaches for understanding and predicting the function of individual forms of these enzymes. A related goal is the production of soluble forms of mammalian cytochromes P450 for X-ray crystallography.
Databáze: OpenAIRE