| Autor: |
Kesici H., Ulusoy A.N., Topgül K., Paşaoglu H., Bayraktar N., Şenyürek G., Karaköse O. |
| Přispěvatelé: |
Ondokuz Mayıs Üniversitesi |
| Jazyk: |
turečtina |
| Rok vydání: |
2007 |
| Předmět: |
|
| Popis: |
Purpose: The aim of the study is to investigate the effect of Taurolidine on intestinal anastomosis and wound healing in rats with obstructive jaundice. Material and Methods: In this study 40 male Wistar-Albino rats were used. Rats were not given any food for 12 hours before the procedure and a blood sample was taken for TNF-?. Rats were divided into two groups, each containing 20 rats. The first group was sham group and the second group was obstructive jaundice group that is performed by ligation and division of choleduct. Four days later from the first surgical procedure we performed full thickness incision and anastomosis to the descending colon. Group 1 and 2 were also subdivided within themselves. We administered 200 mg/kg/day isotonic sodium (IS). via intraperitoneal route for the first half and Taurolidine to the second. Rats were sacrificed 7 days after the anostomosis. Anastomotic segments were resected and explosion pressure was measured. Samples were take from these segments for hydroxiproline and histological investigation. Blood samples were also taken for TNF-? and bilirubin. Results: Mean anastomosis explosion pressure in obstructive jaundice-IS group, was statistically significantly lower than the obstructive jaundice-Taurolidine (OJ-T) group and the IS only group (p0.05). Mean tissue hydroxyproline concentration at the anastomosis of OJ-IS group was significantly lower than OJ-T and only IS groups (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
