| Autor: |
Göksel, Sibel, Cengiz, Arzu, Öztürk, Hakan, Yürekli, Yakup |
| Přispěvatelé: |
RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göksel, Sibel |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
Objective: This study aims to determine the prognostic value of metabolic volumetric 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) parameters of the primary tumor, including metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in patients with non-small cell lung cancer (NSCLC). Material and Methods: The study included a total of 102 patients who underwent PET/CT for staging. Histopathological diagnosis, stage of disease, survival time, maximum standard uptake value, MTV, and TLG values of the primary tumor were documented. The Kaplan-Meier test was used to examine the relationships between overall survival (OS) with PET/CT parameters and Tumor-Node-Metastasis stages. Univariate and multivariate Cox regression analyses were applied, and the association between OS with metabolic volumetric PET/CT parameters was estimated. Results: During the follow-up period, 93 (91.17%) patients died. All patients had a median OS of 10.15 months (range 0.5-74 months), whereas patients with M1 disease had a median OS of 7 months (range 0.5-56). The majority of (79.41%) patients had advanced-stage disease. The mean MTV (p=0.012) and TLG (p=0.037) values at the early stage (Stage I-II) were significantly lower than the locally advanced and advanced (Stage III-IV) stage. In univariate analysis, elder age (p=0.004), advanced stage (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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