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Poznato je da većina proizvođača lekova, u svojim uputstvima preporučuje iste doze lekova za ovce i koze. Međutim, treba istaći da postoje određene specifičnosti (drugačiji i brži metabolizam) kod koza, koje uslovljavaju drugačije doze i doziranje lekova kod ovih životinja. Iz tog razloga, doze lekova preporučene za ovce, ili goveda se ne mogu primeniti kod koza. Za ovakvu konstataciju postoji više razloga: pre svega, poluvreme eliminacije nekih lekova, uključujući mnoge antihelmintike, koji se eliminišu uglavnom preko jetre (putem žuči), kod koza je duplo kraće u odnosu na ovce. Iz tog razloga, doze navedenih lekova su za 1,5 do 2 puta veće od onih, koje su preporučene za ovce. Takođe, poluvreme eliminacije meloksikama kod koza je mnogo kraće (6,73 sata) u odnosu na goveda (24 sata) i ovce (10,85 sati). Kako poluvreme eliminacije bilo kog leka direktno utiče na interval doziranja, to znači da se u ovom i sličnim slučajevima, preporučuje kraći interval doziranja lekova kod koza. It is known that most drug manufacturers recommend the same doses of drugs for sheep and goats in their instructions. However, it should be pointed out that there are certain specificities (primarily a different and faster metabolism) in goats, which condition different doses and dosing of drugs in these animals. For this reason, doses of drugs recommended for sheep or cattle cannot be used in goats. There are several reasons for this statement: a) First of all, the elimination half-time of some drugs, including many anthelmintics, which are eliminated mainly through the liver (via bile), is twice as short in goats as compared to sheep. For this reason, the doses of the mentioned drugs are 1.5 to 2 times higher than those recommended for sheep. Also, the elimination half-life of meloxicam in goats is much shorter (6.73 hours) compared to cattle (24 hours) and sheep (10.85 hours). Since the elimination half-life of any drug directly affects the dosing interval, so in this and similar cases, it is recommended a shorter dosing interval in goats. Zbornik radova i kratkih sadržaja |
