Procalcitonin and C-reactive protein in the surgery of inflammatory head and neck diseases—diagnostic significance and correlations

Autor: Yankov, Yanko, Medical University of Varna, Bocheva, Yana
Rok vydání: 2022
Předmět:
Zdroj: Варненски медицински форум; Vol 11, No 1 (2022); 218-225
Varna Medical Forum; Vol 11, No 1 (2022); 218-225
ISSN: 2367-5519
1314-8338
Popis: IntroductionProcalcitonin (PCT) increases its serum levels in bacterial infections and this justifies its introduction into clinical practice as a specific biomarker in inflammation. So far it has not been studied in the surgery of inflammatory diseases of the head and neck.Materials and MethodsThe study included 80 patients with head and neck abscesses over the age of 18 who were tested for C-reactive protein (CRP) and PCT. They were divided into two groups—50 (28 men and 22 women) with odontogenic and 30 (20 men and 10 women) with non-odontogenic abscesses.The control group consisted of 51 age- and gender-matched healthy people.CRP and PCT were determined by latex-enhanced immunoturbidimetric assay—CRP with COBAS 6000 biochemical analyzer and PCT with Advia 1800 biochemical analyzer (Siemens).Results and DiscussionIn the group with odontogenic abscesses, the average value of CRP was 104.94 ± 110.63 mg/L and that of PCT was 0.84 ± 1.01 ng/mL.In the group with non-odontogenic abscesses, the mean value of CRP was 36.85 ± 5.34 mg/L and of PCT was 1.36 ± 1.55 ng/mL.In the control group, the mean value of CRP was 0.806 ± 0.95 mg/L and that of PCT was 0.16 ± 0.13 ng/mL.Significantly higher CRP values were observed in the group with odontogenic abscesses compared to the values of the same indicator in the group with non-odontogenic abscesses. At the same time, the PCT values were higher in the group with non-odontogenic abscesses compared to the same marker in the studied group with odontogenic abscesses.Statistically significantly (p < 0.05) higher values of CRP and PCT were observed in the studied group with odontogenic abscesses compared to the same in the control group.The values of CRP and PCT in the studied group with non-odontogenic abscesses were statistically significantly (p < 0.05) higher than the same marker in the control group.ConclusionAccording to the analysis of the obtained data we can conclude that PCT can be used as a potential laboratory marker in the diagnosis and treatment of patients with odontogenic and non-odontogenic abscesses of the head and neck. It corresponds equally well to CRP values in the clinical diagnosis of these nosological units.
Databáze: OpenAIRE
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