| Autor: |
Tabakan, İbrahim, Öcal, Işıl, Taştekin, Bora, Yuvacı, Ahmet Umut, Pelit, Aykut |
| Přispěvatelé: |
Çukurova Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tabakan, İbrahim, Öcal, Işıl, Taştekin, Bora, Yuvacı, Ahmet Umut, Pelit, Aykut |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
The aim of this study was to evaluate the effect of pulsed magnetic field on cutaneous wound healing in an animal burn model and to determine the dose-duration parameters of the magnetic field which may help to enhance the second degree deep burn model. A total of 40 adult Wistar Albino rats were used in the study. The “comb burn model” defined by Regas was used to create a 2nd-degree deep contact burn on the rats’ back. Rats divided into five groups; the C-B (control; burned rats), S-B (burned rats dressed with saline), AP-B (burned rats dressed with antibiotic pomade rats), C-PMF1 (Burned rats exposed to pulsed magnetic field for 1 week) and C-PMF2 (Burned rats exposed to pulsed magnetic field for 2 week) groups. Pulsed magnetic field application (1.5mT and 40Hz): Plexiglass cages with up to 5 rats were placed between Helmholtz coils and the whole system was isolated in Faraday cage. The rats in C-PMF1 group were exposed to the pulsed magnetic field for 1 hour, while those in C-PMF2 were exposed for 2 hours once a day during the 14-day experimental period. After 2 weeks, the burnt areas were excised and the presence of neutrophil infiltration, vascularization and epithelialization in the zone of stasis were examined histopathologically. As a result of histopathological examinations, neutrophil infiltration was found to be higher in C-B, SB, AP-B and C-PMF1 groups, and less in C-PMF2 group, whereas fibroblast count was higher in CPMF2 and less in other groups. While vascularization was significantly higher in C-PMF2 group, no significant difference was found between the other groups. Consequently, since the recovery period of burn wounds may affect patient mortality. The pulsed magnetic field to be applied at the appropriate dose and duration may be an adjunctive therapy in the treatment of burn patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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