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WOS: 000399405200003 Purpose: The puspose of this study was to find the level of effectiveness and reliability of AMH (anti-mullerian hormone) in indicating the over reserve of IVF patients in comparison with other reserve indicators used. Materials and Methods: The study included 89 infertile couples ages between 18 and 45. Basal serum FSH, LH, E2, prolactin, fT3, fT4 and TSH, AMH levels of female patients were measured in the 3rd day of menstruation. Ovary volume and AFC(antral follicle count) were determined through transvaginal ultrasound. In our study, all patients were subjected to long protocol with GnRH agonist. Oocyte numbers equal to or higher than 4 were included in the " good response" group and oocyte numbers lower than 4 were included in the "poor response" group. Afterwards, the results obtained were statistically compared with other parameters used for determination of ovarian reserve. Results. Significant differences were present between two groups in terms of age, serum FSH, AMH levels, hCG day E2 levels, number of antral follicles, hCG day follicle numbers and mature oocyte numbers. When the cutoff value for AMH was taken to be 0,24 ng/ml, sensitivity and specifity were determined to be 82.1% and 72.7% respectively. Conclusion: There is a strong relationship between serum AMH level and the ovarian response of the patients. Besides, AMH levels were determined to be in relation with the pregnancy rate. |
