| Autor: |
Öcal, Işıl, Taştekin, Bora, Çoban, Fatma, Yılmaz, M. Bertan, Pelit, Aykut, Günay, İsmail |
| Přispěvatelé: |
Çukurova Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Öcal, Işıl, Taştekin, Bora, Çoban, Fatma, Yılmaz, M. Bertan, Pelit, Aykut, Günay, İsmail |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
Introduction: Functional impairments that occur in uterine contractions lead to many gynecological disorders in pregnancy terms. The present study was aimed at determining the role of concentrations of calcium ion how uterine smooth muscle contraction parameters were modulated by pulsed-magnetic field (PMF) with respect to varying contraction parameters in pregnancy terms of rats. Methods: Pregnant fifty-six Wistar Albino divided into 8 groups (in each group, n= 7) according to pregnancy terms; Exposed-pulsed magnetic field (Control, Early-PMF, Middle-PMF and Late-PMF of pregnancy terms) pregnant rats and unexposed pregnant rats groups. Uterine rings were allowed to equilibrate at 1.5 g tension for 60 min, after which the preparations were challenged twice by administration of a maximally effective concentration of oxytocin(1mU/mL). When the contractions became regular, they were exposed to increasing cumulative manner calcium concentrations (10-4, 10-3 and 10-2 M) in Ca2+-free Krebs solution. Results: The uterine contraction parameters were analyzed as gram force (gf) and area under the curve (AUC). At the early-term of pregnancy, contraction force and AUC increased in exposed to pulsed magnetic field groups compared to the control groups. While uterine rings treated with 10-4 and 10-3 M Ca2+ could not observe any considerable values, it was found significant results in those treated with 10-2 M Ca2+. Conclusion: Findings suggest that non-invasive pulsed magnetic field application may help prevent unpleasant symptomatic progression in late terms of gestation. Detailed examination of the L-type Ca2+ channels which play an important role in the contraction will be death with later on. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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