Polymorphisms of glutathione-s-transferase M1, T1, and P1 genes in endometrial carcinoma
| Přispěvatelé: | Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Bölümü., Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı., Özerkan, Kemal, Atalay, Mehmet Aral, Yakut, Tahsin, Doster, Y., Yılmaz, Emel, Karkucak, Mutlu, AAH-9791-2021, ABI-5648-2022 |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Blood sampling
Glutathione transferase Multiplex polymerase chain reaction Null allele Cancer staging Gene Endometrium Cancer risk Obstetrics & gynecology Middle aged Glutathione S-Transferase M1 Cytochrome P-450 CYP1A1 Genotype Endometrium carcinoma Aged 80 and over Glutathione s-transferase pi Oncology Female Multigene family Restriction fragment length polymorphism Lung-cancer Human Adult Glutathione-s-transferase Bladder Population Genotypes Case-control studies Major clinical study Adenocarcinoma Polymorphism genetic Caucasian Assosciation Article Glutathione transferase M1 Advanced cancer Humans Family Polymorphism Gst Endometrial neoplasms Aged Genetic risk Genetic predisposition Carcinoma Pi Gene frequency Glutathione transferase T1 Susceptibility DNA polymorphism Glutathione transferase P1 Genetic association Maetabolism Prospective studies Controlled study |
| Popis: | Objective: To investigate the polymorphism rates and possible roles of glutathione-s-transferase M1, T1, and P1 gene polymotphisms in the predisposition to endometrial cancer in Caucasian women. Materials and Methods: Serum samples and medical records were collected from 53 Caucasian women with newly diagnosed endometrial cancer and 67 women of the same race without any known history of cancer. Multiplex polymerase chain reaction (PCR) analysis was used to assess glutathione-s-transferase M1 (GSTM1) and T1 gene polymorphisms. Polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) method was used in salvage of GSTP1 gene polymorphism. Results: Frequencies of GSTM1 and GSTT1 null genotypes were not significantly different between the controls and patients with endometrial cancer (56.7% vs 52.8%, p = 0.671; 32.8% vs 26.4%, p = 0.574, respectively). The authors were not able to demonstrate any association between neither GSTP1 genotypes nor allele frequencies and endometrial carcinoma in the population studied (p = 0.310, p = 0.318, respectively). Moreover, no significant association could be demonstrated with GSTM1 and GSTT1 polymorphisms and clinical stages of endometrial cancer. Nevertheless, there was a significant difference between the frequencies of GSTP1 AA and GG genotypes in relation to Stage I disease when compared with advanced stages of endometrial carcinoma (p = 0.03). In addition, no association was found between polymorphisms of GST suspergene family and non-endometrioid type endometrial carcinomas. Conclusion: These results suggest that GSTT1, GSTM1, and GSTP1 polymorphisms are not associated with endometrial cancer in the Caucasian population. |
| Databáze: | OpenAIRE |
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