Low dose dopamine prevents end organ damage in experimentally induced pancreatitis
| Autor: | Arslan, Ali, Aliyazıcıoğlu, Yüksel, Güven, Hakan, Aydın, Oğuz, Özkan, Kayhan |
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| Přispěvatelé: | Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı., Kaya, Ekrem, AAG-7319-2021 |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Male
Lung parenchyma Rats sprague-dawley Dopamine Amylase blood level Pathogenesis Animal tissue Fluid therapy Acute lung injury Enzyme activity Vasoactive agent Lung Ringer lactate solution Priority journal Myeloperoxidase Base deficit Lung injury Mean arterial pressure Dose-response relationship drug Cytokines Vasodilator agents Resuscitation Histopathology Pancreas duct Lactated ringer Disease models Severity Article Low drug dose Blood gas analysis Microcirculatory impairment Myeloperoxicase activity Animals Animal model Animal experiment Hemorrhagic-pancreatitis Acute disease Peroxidase Organ injury Animal Amylase Nonhuman Multiple organ failure Rectum temperature Rats Pancreatitis Ceruletide Amylases Triacylglycerol lipase blood level Leukocyte count Dopamine receptor Triacylglycerol lipase Taurocholic acid Rat Surgery Therapy Gastroenterology & hepatology Controlled study Model |
| Popis: | Background/Aims: End organ damage due to microcirculatory failure plays an important role in the pathogenesis of acute pancreatitis (AP). The aim of this study was to investigate whether dopamine, a vasoactive agent, is beneficial in the prevention of local and systemic injury in acute pancreatitis. Methodology: Pancreatitis was induced in rats with 5% Na-taurocolic acid infusion into the pancreatic duct. Rats were resuscitated for four hours with saline in the pancreatitis group (P), lactated ringer's (LR) solution in the LR group and low dose dopamine (5 mu g/kg/min) + LR in the D-LR group. The sham group (S) underwent pancreatic duct cannulation only. Rectal temperature (RT) and mean arterial pressure (MAP) were monitored throughout the experiment. Blood samples for amylase, lipase, WBC and blood gas analysis were taken at baseline and at the end of the study. All rats were sacrificed at the 4th hour and pancreatic and lung tissues were removed for histopathological examination and tissue myeloperoxidase (MPO) activity. Results: MAP was lower in the P and LR groups than the sham and the D-LR groups. RT was higher in P and LR groups than the sham and the D-LR groups. Base deficit was higher in the P group than the sham and the D-LR groups. The lung MPO activity was higher in the P group than all the others. Lung MPO activity that is closest to the sham was that of D-LR group's. The pancreatic MPO activity was found to be increased in the P and decreased in the LR groups. Conclusions: In this experimental model for AP, low dose dopamine + LR resuscitation attenuates the lung injury but not the local pancreatic injury. |
| Databáze: | OpenAIRE |
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