Divergent modulation of proteostasis in prostate cancer
| Autor: | Kırmızıbayrak, Petek Ballar, Gözen, Oğuz, Erzurumlu, Yalçın, Barrio, R, Sutherland, JD, Rodriguez, MS |
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| Přispěvatelé: | Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Moleküler Biyoloji ve Genetik Bölümü., Tepedelen, Burcu Erbaykent, CNH-6913-2022 |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Unclassified drug Biochemistry & molecular biology Carcinogenesis Protein function Carboxy terminal sequence Androgen Unfolded protein response Amino terminal sequence Wild-type spop Regulator protein Pathology Cyclin D1 Cancer inhibition Proteasome endopeptidase complex Oncogene myc Priority journal Prostate cancer Cell-proliferation Transcriptional activity Cyclin dependent kinase inhibitor 1B Cullin RING ubiquitin ligase Endoplasmic reticulum associated degradation Androgen receptor Ubiquitin ligase SIAH2 Protein p27 Prostate tumor Deubiquitination Prostatic neoplasms Deubiquitinating enzymes Protein homeostasis Prostate specific antigen Protein NKX 3 1 Protein p21 Human Research & experimental medicine DNA repair Ubiquitin protein ligase NEDD4 Amino acid sequence Protein kinase B Ubiquitin-like Homeobox gene Autophagy Tumor-suppressor gene Humans Phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase Medicine research & experimental Deubiquitinase Ubiquitin-Specific Proteases Ubiquitin RING finger E3 ubiquitin ligase Androgen receptor-activty Proteasome Deubiquitinating enzyme USP12 Ubiquitination Sumoylation Nonhuman Ligase Metabolism Myc protein Proteostasis Enzymology Protein expression Heat-shock proteins Cell nucleus receptor Autophagy (cellular) Endoplasmic reticulum-associated degradation Epithelial mesenchymal transition Ubiquitin protein ligase E3 Phosphatidylinositol 3 kinase |
| Popis: | Proteostasis regulates key cellular processes such as cell proliferation, differentiation, transcription, and apoptosis. The mechanisms by which proteostasis is regulated are crucial and the deterioration of cellular proteostasis has been significantly associated with tumorigenesis since it specifically targets key oncoproteins and tumor suppressors. Prostate cancer (PCa) is the second most common cause of cancer death in men worldwide. Androgens mediate one of the most central signaling pathways in all stages of PCa via the androgen receptor (AR). In addition to their regulation by hormones, PCa cells are also known to be highly secretory and are particularly prone to ER stress as proper ER function is essential. Alterations in various complex signaling pathways and cellular processes including cell cycle control, transcription, DNA repair, apoptosis, cell adhesion, epithelial-mesenchymal transition (EMT), and angiogenesis are critical factors influencing PCa development through key molecular changes mainly by posttranslational modifications in PCa-related proteins, including AR, NKX3.1, PTEN, p53, cyclin D1, and p27. Several ubiquitin ligases like MDM2, Siah2, RNF6, CHIP, and substrate-binding adaptor SPOP; deubiquitinases such as USP7, USP10, USP26, and USP12 are just some of the modifiers involved in the regulation of these key proteins via ubiquitin-proteasome system (UPS). Some ubiquitin-like modifiers, especially SUMOs, have been also closely associated with PCa. On the other hand, the proteotoxicity resulting from misfolded proteins and failure of ER adaptive capacity induce unfolded protein response (UPR) that is an indispensable signaling mechanism for PCa development. Lastly, ER-associated degradation (ERAD) also plays a crucial role in prostate tumorigenesis. In this section, the relationship between prostate cancer and proteostasis will be discussed in terms of UPS, UPR, SUMOylation, ERAD, and autophagy. European Cooperation in Science and Technology (BM1307) Ege Üniversitesi Bilim Akademisi |
| Databáze: | OpenAIRE |
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