| Autor: |
Tutun, U, Ulus, AT, Katircioglu, SF, Can, Zeki, Surucu, S, Apaydin, Nusret, Saritas, Z, Kaplan, S, Pamuk, K, Ozgencil, E, Aksoyek, A |
| Jazyk: |
angličtina |
| Rok vydání: |
2003 |
| Popis: |
Objectives: To evaluate the effects of intravenous magnesium sulfate (Mg2SO4) administration on ischemia-reperfusion injury of the spinal cord. Material and Methods: Sixteen rabbits were randomly assigned to the control ( group I, 8 rabbits) and the study group ( group II, 8 rabbits). The abdominal aorta was clamped for a period of 30 min followed by a reperfusion period of 60 min. The animals in group II received 0.25 ml/kg/h Mg2SO4 intravenous infusion (15% Mg2SO4) throughout this procedure. The animals were then observed for 24 h after which their neurological states were evaluated and tissue samples obtained from the spinal cord were examined with electron microscopy. Results: Aortic pressure distal to the cross-clamp during the occlusion period was 9 +/- 3 mm Hg in group I and 19 +/- 6 mm Hg in group II. All animals in group I were paraplegic at the end of the study. In group II the neurological outcome of 1 animal was poor while the other 7 animals were neurologically in a good condition. Electron microscopic examinations of the spinal cord tissues of group I revealed severe injury but the ultrastructure was well preserved in group II. Conclusions: Intravenous Mg2SO4 administration may have protective effects on the ischemia-reperfusion injury of the spinal cord. We propose that Mg2SO4 may be an additional protective pharmacological agent in thoracal and thoracoabdominal aortic surgery. Copyright (C) 2004 S. Karger AG, Basel. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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