| Popis: |
Vascular complications in the course of type 11 diabetes mellitus are the most important causes of mortality and morbidity. Many different factors such as hemodynamic, neurohumoral, metabolic factors and cytokines have attributed to diabetic vasculopathy. Recently, the role of platelets in diabetic vasculopathy has been shown. In this study, we aimed to investigate the platelet function tests in diabetic patients according to their complications and, mean platelet volume and in-vitro platelet aggregations in patients with type 11 diabetes mellitus. Fifty two diabetic patients with complications and 48 pateints without complications were included into this study. Mean platelets volume measurements and in-vitro platelet aggregations with ADP, collagen and epinephrine were obtained in all patients. As a result; there are no statistically differences between the group with complications and the group without any complications in the aspect of mean platelet volumes and in-vitro aggregation tests. Although the role of platelets regarding diabetic complications in diabetic patiens is well-known phenomenon, we could not find any differences between the complication and non-complication group. This could be explained by the differences between in-vitro aggregation and in-vivo platelet functions. In-vitro platelet aggregation tests can not exactly reflect the in-vivo platelet funtions in different disease and patients. The another mechanism for explanation this phenomenon could be the rapid consumption of activated platelets from blood circulation in diabetic patients with complications. Further studies are needed to explain the in-vivo role of platelets in diabetic complications. |
