Up-regulation of serine/threonine protein phosphatase type 2A regulatory subunits during methylprednisolone-induced differentiation of leukaemic HL-60 cells

Autor:	Aydin, HH, Selvi, N, Saydam, G., Tobu, M, Uzunoglu, S, Uslu, R, Buyukkececi, F, Omay, SB
Přispěvatelé:	Ege Üniversitesi
Jazyk:	angličtina
Rok vydání:	2000
Předmět:	leukaemia differentiation methylprednisolone HL-60 cells PP2A
Popis:	WOS: 000165827500004 PubMed ID: 11122267 Serine/threonine protein phosphatase 2A (PP2A) may play a role in leukaemic cell differentiation of the HL 60 myeloid leukaemic cell-line after methylprednisolone induction. We have investigated the specific enzyme activity and expression of catalytic and regulatory subunits of PP2A. The resulting specific enzyme activity and immunoblots showed an increase in enzyme activity and the expression of regulatory subunits after methylprednisolone treatment. There was no change in the expression of PP2A catalytic subunits. It is suggested that the effect of methylprednisolone on leukaemic differentiation may be the result of PP2A upregulation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=od______9436::155323a9a5d5c9a3beb9f7bde3d56452 https://hdl.handle.net/11454/35982 Zobrazit plný text záznamu