Serum amyloid a and lipoprotein associated phospholipase a levels in patients with malign melanoma: Correlations2 with clinical assessment and stage [Malign melanomlu hastalarda serum amiloid a ve lipoprotein İlişkili fosfolipaz a düzeyleri: Klinik değerlendirme ve evre2 ile korelasyon]
| Autor: | Kayaş Y., Sağın F., Akçay Y., Yenipazar G.K., Azarsız E., Sözmen E., Özdemir F., Karaarslan I. |
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| Přispěvatelé: | Ege Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Popis: | Objective: The lack of validated, sensitive, and specific biomarkers for early diagnosis and follow-up of patients with malign melanoma (MM) is a major problem today. In this study, we aimed to investigate the correlations of two inflammatory biomarkers-serum amyloid A (SAA) and lipoprotein associated phospholipase A2 (Lp-PLA2)-in clinical follow-up and staging of MM. Methods: Lactate dehydrogenase (LDH) and C-reactive protein (CRP) (Routine), SAA and S100B (ELISA), and Lp-PLA2 (PLAC® Test) activity levels were examined in histologically and clinically confirmed MM patients (n=131) and in healthy controls (n=27). Results: Sedimentation rate and LDH, CRP, S100B, SAA, Lp-PLA2 activities were found to be significantly higher in MM patients compared to control group (p Tip-076 This work was funded by a fund from Ege University Research Project Fund (Tip-076). |
| Databáze: | OpenAIRE |
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