| Autor: |
Ojha, Mohit, Joshi, Rashika, Goodman, Emily Margaret, Lewis, Jana, Fan, Qiang, Schumann, Richard, Porollo, Aleksey, Batie, Matthew, Varisco, Brian Michael |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| DOI: |
10.1101/2020.04.27.20075531 |
| Popis: |
Emphysema is an important element of many progressive lung diseases, with chronic obstructive pulmonary disease (COPD) being the most common. With the exception of α 1-antitrypsin (AAT) replacement therapy there are no disease modifying therapies for progressive emphysema. We previously reported that alveolar type 2 (AT2)-cell synthesized CELA1 is neutralized by AAT and that CELA1 is necessary for emphysema in AAT-deficiency. Here, we use mouse models and human tissues to show that CELA1 is required for progressive emphysema. In mice, lung injury was induced with tracheal porcine pancreatic elastase. Cela1 began increasing at 21-days, and Cela1-/- mice were protected from continued airspace enlargement at 42 and 84 days (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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