Effect of 3 '-4 '-dihydroxyflavonol on lipid per oxidation in experimental renal ischemia-reperfusion in rats
| Autor: | Koç, Aynur., Ergene, Neyhan., Baltaci, Abdulkerim Kasim., Mogulkoc, Rasim. |
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| Přispěvatelé: | Selçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Baltaci, Abdulkerim Kasim., Mogulkoc, Rasim. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Popis: | WOS: 000493109500007 PubMed: 31969289 This study aimed to examine the affects of 3'-4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental renal ischemia-reperfusion. The research was conducted on Wistar-albino type male rat. The experimental groups were formed as 1.Control; 2.Sham; 3.Ischemia; 4.Ischemia+reperfusion; 5.DiOHF+Ischemia; 6.Ischemia+ DiOHF + reperfusion. The highest tissue glutathione levels were found in groups 5 and 6. Groups 1 and 2, which were control and sham groups respectively, had the lowest tissue GSH values. Ischemia group was found to have the highest tissue malondialdehyde (MDA) level. Tissue MDA levels in group 4 were lower than those in group 3, however, higher than the levels in all other groups. Erythrocyte GSH levels in groups 5 and 6 were higher than the levels in all other groups. Group 4 has highest plasma MDA values. Plasma MDA levels in group 3 were lower than the levels in Group 4, but higher than those in other groups. The results of the study indicate that intraperitoneal DiOHF administration inhibits lipid per oxidation that intensifies in the case of renal ischemia-reperfusion injury in rats. Necmettin Erbakan University, Scientific Research Council [NEU-BAP-131318001] This study was supported by a grant Necmettin Erbakan University, Scientific Research Council (Grant number is NEU-BAP-131318001). The authors declare that there are no conflicts of interest. |
| Databáze: | OpenAIRE |
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