| Autor: |
Đunić, Irena, Dopsaj, Violeta, Miljić, Predrag, Suvajdžić-Vuković, Nada, Tomin, Dragica, Virijević, M., Novković, Aleksandra, Elezović, I. |
| Rok vydání: |
2014 |
| Zdroj: |
Haematologica |
| Popis: |
Background: Haemophilic arthropathy is the main cause of morbidity in indi- viduals with severe haemophilia and prevention of joint disease is the primary goal of treatment. Recurrent bleeding into joints causes damage to all joint structures, but the precise mechanism by which this induces haemophilic arthropathy is still unclear. Recently, it was shown that one effect of blood in the joint is degradation of cartilage. Biomarkers of cartilage turnover can be meas- ured in physiological fluids, such as plasma and urine. Aims: The aims of this study were to detect correlation between a marker of oxidative stress -advanced oxidation protein products (AOPP) and serum/urine concentrations of biomarkers of joint cartilage degradation, as well as to esti- mate the influence of different prophylaxis regimens for severe haemophilia on this process. Methods: The study included 20 adult patients with severe haemophilia, man- ifested by plasma factor (F)VIII/IX |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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