Serum neutrophil gelatinase-associated lipocalin levels in patients with non-dipper hypertension

Autor: Aksan G., Inci S., Nar G., Siğirci S., Gedikli Ö., Soylu K., Nar R., Yüksel S., Şahin M.
Přispěvatelé: Aksan, G., Deparment of Cardiology, Şişli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey -- Inci, S., Departmant of Cardiology, Aksaray State Hospital, Aksaray, Turkey -- Nar, G., Departmant of Cardiology, Aksaray State Hospital, Aksaray, Turkey -- Siğirci, S., Deparment of Cardiology, Şişli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey -- Gedikli, Ö., Department of Cardiology, Artvin State Hospital, Artvin, Turkey -- Soylu, K., Department of Cardiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey -- Nar, R., Department of Biochemistry, Aksaray State Hospital, Aksaray, Turkey -- Yüksel, S., Department of Cardiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey -- Şahin, M., Department of Cardiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Popis: PubMed ID: 25864997
Purpose: Neutrophil gelatinase-associated lipocalin (NGAL) is a protein belonging to the lipocalin superfamily and plays a role in atherosclerosis, renal injury and inflammation. The present study aimed to investigate serum NGAL concentrations in groups of patients with dipper and non-dipper hypertension (HT) and to characterize the relationship between NGAL concentration and circadian blood pressure in hypertensive patients. Methods: A total of 41 (22 male, 19 female, mean age: 56.1 ± 8.9 years) non-dipper HT patients, 40 (19 male, 21 female, mean age: 54.0 ± 10.0 years) dipper HT patients and 42 age- and gender-matched healthy individuals were enrolled in the study. Dipper and non- dipper HT were diagnosed via ambulatory blood pressure monitoring. Serum NGAL concentrations were measured by enzyme-linked immunosorbent assay from blood samples obtained from patients. Results: Serum NGAL concentrations were found to be significantly higher in the non- dipper and dipper HT patient groups in comparison with the control group (84.9 ± 23.0 ng/ml and 62.1 ± 17.8 vs. 46.6 ± 13.7 ng/ml, p
Databáze: OpenAIRE
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