| Autor: |
Ribeiro Morais, G., Kniess, T., Bergmann, R., Gano, L., Abrunhosa, A., Santos, I., Paulo, A. |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Zdroj: |
Applied Radiation and Isotopes 82(2013), 100-104 |
| Popis: |
The formation of β-amyloid deposits is considered a histopathological feature of Alzheimer´s disease (AD). In vivo molecular imaging by means of amyloid-avid radiotracers will allow for an early and conclusive diagnostic of AD. Herein, we describe the radiosynthesis of the radiofluorinated styryl benzoxazole derivative [18F]-[2-[N-methyl-N-(2`-fluoroethyl)-4`-aminostyryl]benzoxazole] ([18F]-1) and its pre-clinical evaluation, including metabolic and biodistribution studies in male Wistar rats. The in vivo biological evaluation of [18F]-1 showed that this new radiotracer has a moderate brain uptake with a slow brain washout and a poor in vivo stability. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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