| Autor: |
Abdulrahman, H., Hafdi, M., Mutsaerts, H. J. M. M., Nederveen, A. J., Petr, J., Gool, W. A., Richard, E., Dalen, J. |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Cerebral Circulation, Cognition and Behavior 3(2022), 100125 |
| Popis: |
Background. The arterial spin labeling-spatial coefficient of variation (sCoV) is a new vascular magnetic resonance imaging (MRI) parameter that could be a more sensitive marker for dementia-associated cerebral microvascular disease than the commonly used MRI markers cerebral blood flow (CBF) and white matter hyperintensity volume (WMHV). Methods. 195 community-dwelling older people with hypertension underwent MRI twice with a three-year interval. Cognition was evaluated every two years for 6-8 years using the mini-mental state examination (MMSE). Dementia diagnoses were registered up to 9 years after the first scan. We assessed relations of sCoV, CBF and WMHV with cognitive decline during follow-up, and compared MRI parameters between participants that did and did not develop dementia. Results. sCoV and CBF were not associated with MMSE changes during 6-8 years of follow-up and did not differ between participants who did (n=15) and did not (n=180) develop dementia. Higher WMHV was associated with declining MMSE scores (-0.15 points/year/ml, 95%CI=-0.30; -0.01), and with participants who developed dementia after the first MRI (13.3 vs 6.1mL, p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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