Effects of different cardioplegic solutions on nitric oxide release from coronary vasculature in diabetic patients undergoing coronary artery bypass surgery
| Autor: | Karaca P., Yurtseven N., Enç Y., Aksoy T., Sokullu O., Bilgen F., Canik S. |
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| Přispěvatelé: | Maltepe Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: | |
| Popis: | PubMed ID: 17162282 Objective: The aim of this study was to compare the effects of two different cardioplegic solutions on nitric oxide (NO) release from coronary vasculature in patients with type II diabetes mellitus undergoing coronary artery bypass grafting (CABG) surgery. Methods: Forty patients undergoing elective CABG surgery were randomized to be given crystalloid (Group 1) or blood (Group 2) cardioplegia. Aortic and coronary sinus blood samples were taken at three different time periods and the release of NO from the coronary vasculature was determined by measuring its stable end-products, nitrite and nitrate. The difference between the aortic and coronary sinus concentrations of nitrite and nitrate represents the amount of NO released by coronary vascular bed. Results: Before application of aortic cross-clamp, at T1 period, the levels of nitrite/nitrate from the coronary vasculature were similar in both groups (6.53±1.21 µM vs 6.07±1.24 µM, p> 0.05). However after the removal of cross-clamp, a significant decrease in NO was observed in Group 1 as compared with Group 2 (4.21±0.73 µM vs 4.92±1.02 µM, p< 0.01). This decrease persisted at T3 period, after 30 minutes of reperfusion in group 1 being significantly different from group 2 (3.86±0.49 vs 4.37±0.72 µM, p |
| Databáze: | OpenAIRE |
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