Tumor volumetry as predictive and prognostic factor in the management of ovarian cancer
| Autor: | Andreopoulou, E., Andreopoulos, D., Adamidis, K., Fountzila-Kalogera, A., Fountzilas, George, Dimopoulos, M. A., Aravantinos, Gerasimos, Zamboglou, N., Baltas, D., Pavlidis, Nicholas |
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| Přispěvatelé: | Pavlidis, Nicholas [0000-0002-2195-9961], Aravantinos, Gerasimos [0000-0002-2106-1713] |
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Adult
Paclitaxel Ovary cancer Drug response Computer program Major clinical study Ca-125 antigen Article Ovarian neoplasms Carboplatin Cancer growth Volumetry Ovarian cancer Advanced cancer Computer assisted tomography Humans Chemotherapy Predictive value of tests Tumor volume Middle aged Quantitative analysis Aged Priority journal Disease progression Platinum derivative Quantitative diagnosis Follow up Prognosis Cancer survival Cancer combination chemotherapy Algorithm Retrospective studies Retrospective study Residual Neoplasm staging Prognostic and predictive factor Neoplasm Female Cisplatin Prediction Human |
| Zdroj: | Anticancer Research |
| Popis: | Background: The usefulness of tumor volumetry in ovarian epithelial cancer has never been intensively investigated. The aim of the present study was to determine the value of quantitative analysis of tumor volume as a predictive method for response to treatment and as a prognostic method for disease outcome. Materials and Methods: Seventy-five women with advanced ovarian cancer who presented with measurable disease on CT scan prior to chemotherapy were retrospectively studied. The patients were treated with platinum-based chemotherapy. The median follow-up was 113.36 weeks. An independent radiologist identified and delineated tumor contours in each slice of sequential CT scans before and after therapy. Volumetry was measured with a three-dimensional approach by utilizing a digitizer and a specific algorithm on a software computed program. Results: Data were analyzed according to initial and to residual tumor volumes. Patients with low initial volume of 165 CM3) initial tumor volume had a shorter time to progression (p |
| Databáze: | OpenAIRE |
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