Prognostic variables in patients with advanced colorectal cancer treated with fluorouracil and leucovorin-based chemotherapy
| Autor: | Fountzilas, George, Gossios, K., Zisiadis, A., Svarna, E., Skarlos, Dimosthenis V., Pavlidis, Nicholas |
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| Přispěvatelé: | Pavlidis, Nicholas [0000-0002-2195-9961] |
| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Laboratory test Survival rate Cancer localization Antimetabolites Alpha2b interferon Gamma glutamyltransferase Leucovorin Major clinical study Review Cancer staging Prognostic factors Article Colorectal neoplasms Metastasis Advanced cancer Alkaline phosphatase Pathology Humans Chemotherapy Treatment outcome Mortality Analysis of variance Colorectal tumor Middle aged Aged Priority journal Albumin Medical record Folinic acid Lactate dehydrogenase Dipyridamole Prognosis Colorectal cancer Antineoplastic Cancer survival Cancer combination chemotherapy Retrospective studies Retrospective study Risk factors Clinical feature Neoplasm staging Carcinoembryonic antigen Female Fluorouracil Risk factor Antineoplastic antimetabolite Human |
| Zdroj: | Medical and pediatric oncology |
| Popis: | Possible prognostic variables for tumor response, time to progression (TTP), and survival in 141 patients with advanced colorectal cancer treated with fluorouracil and leucovorin-based chemotherapy were analyzed. None of the variables examined for their possible influence on tumor response attained significance in the stepwise logistic regression. In the univariate analysis, variables found to be strongly associated with TTP were performance status (PS) (P = 0.0301), liver involvement (P = 0.030), and the initial values of WBC (P = 0.0319), lactic dehydrogenase (LDH; P = 0.0053), γ- glutamyl-transpeptidase (γ-GT; P = 0.0013), alkaline phosphatase (ALP; P = 0.0186), albumin (P = 0.0004), and carcinoembryonic antigen (CEA; P = 0.0014). In the Cox analysis, liver involvement (P = 0.0553), albumin (P = 0.0181), PS (P =0.0484), and ALP (P = 0.0553) were retained as independently significant variables. When only patients with liver metastases were included in the analysis, then only albumin (P |
| Databáze: | OpenAIRE |
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