Cancer of unknown primary during pregnancy: An exceptionally rare coexistence
| Autor: | Pavlidis, Nicholas, Peccatori, Fedro A., Lofts, F., Greco, F. A. |
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| Přispěvatelé: | Pavlidis, Nicholas [0000-0002-2195-9961], Peccatori, Fedro A. [0000-0001-8227-8740] |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Survival rate
Placenta Pelvis metastasis Review Metastasis Pregnancy Neoplasms Live birth Cytoreductive surgery Treatment outcome Liver metastasis Bladder metastasis Central nervous system metastasis Systemic therapy Unknown primary Medline Prognosis Lung metastasis Bone marrow metastasis Female Heart metastasis Human Clinical article Histopathology Article Placental in-vasion Cancer of unknown primary Peritoneum metastasis Humans Muscle metastasis Human tissue Mortality Cyclophosphamide Platinum Adrenal metastasis Neoplastic Cancer prognosis Laparotomy Lymph node metastasis Spleen metastasis Cancer of unknown primary site Cancer center Pregnant woman Bone metastasis Gestational age Surgical technique Taxane derivative Trastuzumab Gemcitabine Cancer survival Treatment Intestine metastasis Pregnancy complications Vemurafenib Doxorubicin Cancer patient Breast metastasis Diaphragm metastasis |
| Zdroj: | Anticancer Research |
| Popis: | Background: Cancer in pregnancy is a rare disease with breast cancer, cervical cancer, melanoma and Hodgkin's disease to be the most commonly diagnosed malignancies during gestation. Cancer of unknown primary (CUP) is a wellrecognized clinical disorder where the primary site can not be identified after a standard diagnostic approach. CUP in pregnancy has rarely been described. Materials and Methods: We searched MEDLINE and contacted cancer Centers in Europe, United States and Australia where patients with CUP or pregnant patients with cancer were diagnosed and treated. Results: Since 1976 we identified 18 pregnant women with CUP in a median gestational age of 34 weeks. Most of these patients were diagnosed with poorly-differentiated histology, had poor response to systemic treatment and a median maternal survival of 8 months. Seventy-two percent of mothers have died, while 80% of the newborns were alive and healthy. Almost one fourth of placentas examined showed metastatic disease. Conclusion: CUP during pregnancy is a very rare coexistence, usually has an aggressive disease with poor response to chemotherapy and a dismal prognosis. Both obstetricians and oncologists should be aware of this rare condition. 35 1 575 580 |
| Databáze: | OpenAIRE |
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