The clinical significance of bcl-2 overexpression in breast cancer patients - A retrospective study with long term follow up
| Autor: | Bai, M. C., Agnantis, Niki J., Zagorianakou, P., Kamina, S., Nonni, A. V., Pavlidis, Nicholas, Briassoulis, E. Ch |
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| Přispěvatelé: | Pavlidis, Nicholas [0000-0002-2195-9961] |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Adult
Conference paper Complete expression Protein bcl 2 Breast carcinoma Major clinical study Follow up Prognosis Cancer staging Immunohistochemistry Retrospective study Clinical feature Protein analysis Protein expression Female Bcl-2 Treatment outcome Disease course Controlled study Human Aged Priority journal |
| Zdroj: | Electronic Journal of Pathology and Histology |
| Popis: | We examined by immunohistochemistry the expression of the bcl-2 protein in sixty-eight cases of operated breast carcinoma patients (stage I, II and III) and correlated the findings with the prognosis. In 38.3% of the cases approximately all neoplastic cells were stained positive (complete expression). A strong impact of complete bcl-2 expression on the clinical outcome was identified (p=0.01). We consider this study as a new approach. There is evidence that the assessment of bcl-2 at the level of complete expression provides important prognostic information for breast carcinoma patients treated surgically. 7 1 94 98 |
| Databáze: | OpenAIRE |
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