Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylasetissue plasminogen activator-mediated thrombolysis
| Autor: | Gerhäuser, C., Mar, W., Lee, S. K., Suh, N., Luo, Y., Kosmeder, J., Luyengi, L., Fong, H. H. S., Kinghorn, A. D., Moriarty, R. M., Mehta, R. G., Constantinou, Andreas I., Moon, R. C., Pezzuto, J. M. |
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| Přispěvatelé: | Constantinou, Andreas I. [0000-0003-0365-1821] |
| Rok vydání: | 1995 |
| Předmět: |
Skin Neoplasms
precancer cancer inhibition 9 10-Dimethyl-1 2-benzanthracene animal experiment HL-60 Cells Organ Culture Support U.S. Gov't P.H.S Gene Expression Regulation Enzymologic animal tissue Mice breast cancer Rotenone retinoic acid drug mechanism ornithine decarboxylase controlled study RNA Messenger Support Non-U.S. Gov't deguelin antineoplastic agent mouse Protein Kinase C Cells Cultured cell culture Mice Inbred BALB C nonhuman cancer prevention Animal fungi article Cell Differentiation legume Neoplasms Experimental Antineoplastic Agents Phytogenic unclassified drug tephrosin priority journal Tetradecanoylphorbol Acetate Female transcription regulation carcinogenesis Precancerous Conditions Human |
| Zdroj: | Nature medicine Nat.Med. |
| Popis: | For the discovery of new cancer chemopreventive agents, we have studied the potential of plant extracts to inhibit phorbol ester-induced ornithine decarboxylase (ODC) activity in cell culture. Four active rotenoids were obtained from the African plant Mundulea sericea (Leguminosae). These isolates were highly potent when evaluated for inhibition of chemically induced preneoplastic lesions in mammary organ culture and inhibition of papillomas in the two-stage mouse skin model, and they appear to function by a unique mechanism at the level of ODC messenger RNA expression. Based on our findings, rotenoids can be regarded as promising new chemopreventive or anticancer agents. © 1995 Nature Publishing Group. 1 260 266 Cited By :97 |
| Databáze: | OpenAIRE |
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