| Autor: |
Foresti, Roberta, Hammad, Jehad, Clark, James E, Johnson, Tony R, Mann, Brian E, Friebe, Andreas, Green, Colin J, Motterlini, Roberto |
| Rok vydání: |
2004 |
| DOI: |
10.1038/sj.bjp.0705825 |
| Popis: |
Carbon monoxide (CO), one of the end products of heme catabolism by heme oxygenase, possesses antihypertensive and vasodilatory characteristics. We have recently discovered that certain transition metal carbonyls are capable of releasing CO in biological fluids and modulate physiological functions via the delivery of CO. Because the initial compounds identified were not water soluble, we have synthesized new CO‐releasing molecules that are chemically modified to allow solubility in water. The aim of this study was to assess the vasoactive properties of tricarbonylchloro (glycinato) ruthenium (II)(CORM‐3) in vitro and in vivo. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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