Neutrophil to lymphocyte ratio (NLR) in patients with rheumatoid arthritis and systemic lupus erythematosus
| Autor: | Pasarić, Antica |
|---|---|
| Přispěvatelé: | Morović-Vergles, Jadranka, Anić, Branimir, Markeljević, Jasenka |
| Jazyk: | chorvatština |
| Rok vydání: | 2019 |
| Předmět: | |
| Popis: | UVOD: Omjer neutrofila i limfocita (NLR) prepoznat je unatrag nekoliko godina kao mogući marker sustavne upale u mnogim malignim, kardiovaskularnim, autoimunim i drugim bolestima. Prema dosadašnjim istraživanjima NLR pozitivno korelira s aktivnosti bolesti u reumatoidnom artritisu (RA), dok su nalazi o NLR u sustavnom eritemskom lupusu (SLE) kontradiktorni. Koliko nam je poznato, nema istraživanja o promjenama broja neutrofila i limfocita u perifernoj krvi bolesnika s RA i SLE i njihovom utjecaju na promjenu NLR. ----- CILJ RADA: Istražiti mehanizam promjene NLR u RA i SLE vezan uz aktivnost bolesti. ----- ISPITANICI I METODE: Ispitivanje je povijesno, a ispitanici su bolesnici s RA (n=181) i bolesnici sa SLE (n=146). Bolesnici su podijeljeni u dvije skupine, u remisiji i s aktivnom bolesti, prema iznosu DAS28CRP (granična vrijednost = 2.6) za RA i iznosu SLEDAI (granična vrijednost = 3) za SLE. Bolesnici s RA podijeljeni su i u dvije skupine prema tome jesu li liječeni glukokortikoidima ili nisu. ----- REZULTATI: NLR i broj neutrofila u perifernoj krvi bolesnika s RA pozitivno koreliraju s iznosom DAS28CRP-a (NLR: r=0.254, p BACKGROUND: Neutrophil to lymphocyte ratio (NLR) has in recent years emerged as a potential marker of systemic inflammation in numerous malignant, cardiovascular, autoimmune and other diseases. Previous studies have found positive correlation between NLR and disease activity in RA, while findings in SLE are contradictory. To our knowledge there is no study of the neutrophil and lymphocyte count changes in peripheral blood of patients with RA and SLE and their impact on the NLR. ----- AIM: Examine the mechanisms behind the NLR change in RA and SLE, associated with disease activity. ----- SUBJECTS AND METHODS: This is a historical study. Subjects are patients with RA (n=181) and patients with SLE (n=146). Patients were divided in two groups, group in remission and group with active disease, with cut-off value of DAS28CRP = 2.6 for RA and SLEDAI = 3 for SLE. Also, patients with RA were divided in two groups according to whether they were treated with glucocorticoids or not. ----- RESULTS: NLR and neutrophil count in peripheral blood of patients with RA are in positive correlation with DAS28CRP (NLR: r=0.254, p |
| Databáze: | OpenAIRE |
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