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Cilj istraživanja. Zadnja izvješća europskih studija ukazuju na promjene u pojavnosti i zastupljenosti upalnih bolesti crijeva na području jugoistočne Europe. Dosadašnja istraživanja pojedinih regija u Hrvatskoj ukazuju na višestruki porast pojavnosti i zastupljenosti upalnih bolesti crijeva. Cilj ovog istraživanja je utvrditi pojavnost i zastupljenost ulceroznog kolitisa i Crohonove bolesti u Splitsko-dalmatinskoj županiji od 2006. - 2012. godine. Metode. U istraživanje su uključeni bolesnici iz Registra za upalne bolesti crijeva Kliničkog odjela za gastroenterologiju i hepatologiju. Podatke u Registar upisivali su i pratili svi licencirani gastroenterolozi na području Splitsko-dalmatinske županije. Svi bolesnici su stariji od 18 godina s potvrđenom dijagnozom ulceroznog kolitisa i Crohnove bolesti po jasno navedenim kriterijima ECCO-a. Istraživanje je presječeno, retrospektivno epidemiološko istraživanje. Rezultati. Tijekom sedmogodišnjeg vremenskog razdoblja od 2006. - 2012. godine u Splitsko-dalmatinskoj županiji registrirano je 553 bolesnika s upalnom bolesti crijeva. Od toga 378 (68,4%) bolesnika s ulceroznim kolitisom i 175 (31,6%) bolesnika s Crohnovom bolešću. Godišnja pojavnost bolesnika s ulceroznim kolitisom u Splitsko-dalmatinskoj županiji od 2006. - 2012. godine je 9/105 (95%CI: 8,2-9,9) i tijekom promatranih godina istraživanja opada. Godišnja pojavnost bolesnika s Crohnovom bolešću je 4/105 (95%CI: 3,4- 4,2) i nije se mijenjala tijekom promatranih godina istraživanja. Pojavnost ulceroznog kolitisa u muškaraca za 1,3 puta je veća nego u žena (χ2=7,3; P=0,007), a kod Crohnove bolesti za 1,75 puta (χ2=7,08; P=0,008). Postoji veći porast zastupljenosti obje bolesti u gradu i na otocima, te među stanovništvom višeg stupnja obrazovanja. Najveći porast zastupljenosti ulceroznog kolitisa nađen u dobnoj skupini početka bolesti od 18-30 godina te 61-70 godina. Za Crohnovu bolest najveći porast zastupljenosti je u dobnoj skupini početka bolesti od 18-30 godina. Među bolesnicima s ulceroznim kolitisom udio pušača je 14%, a među bolesnicima s Crohnovom bolešću 26%. Pozitivnu obiteljsku anamnezu imalo je 14,8 % bolesnika u obje skupine. Zaključak. Pojavnost i zastupljenost ulceroznog kolitisa u našem istraživanju veća je nego u prethodno objavljenim studijama u Hrvatskoj. Tijekom sedmogodišnjeg perioda istraživanja pojavnost ulceroznog kolitisa opada naspram pojavnosti Crohnove bolesti koja se tijekom godina istraživanja ne mijenja. Zastupljenost ulceroznog kolitisa i Crohnove bolesti linearno raste. Aim. Recent reports of european studies have shown some changes in incidance and prevalence of inflamatory bowel disease in south-eastern Europe. Last studies made in some regions in Croatia have shown multiple increase in incidance and prevalence of inflamatory bowel disease. The aim of this study is to determine the incidance and prevalence of ulcerative colitis and Crohn's disease in Split-Dalmatian county in period from 2006-2012 Methods. The research included patients from the Register of inflamatory bowel diseases of the Clinical department for gastroenterology and hepatology. The data were registered and followed up in the Register by all licensed gastroenerologists in the area of Split-Dalmatian county. All the patients were more than 18 years old with confirmed diagnosis of ulcerative colitis and Crohn's disease according to clearly specified criteria of ECCO. The research is an average retrospective epidemiological study. Results. During the seven-year long period from 2006-2012 there were 553 patients registered with an inflamatory bowel disease in Split-Dalmatian county. 378 (68,4%) of them with ulcerative colitis, and 175 (31,6%) patients with Crohn's disease. Annual incidence of patients with ulcerative colitis in Split-Dalmatian county from 2006-2012 was 9/105 (95% CI: 8,2-9,9) and it decreased in the period of followed up years. Annual incidence of patients with Crohn's disease was 4/10 5 (95% CI: 3,4-4,2) and didn't change through the followed up years. Incidance of ulcerative colitis with men was 1,3 times higher than with women (χ2=7,03; P=0,007), and considering Crohn's disease it was 1,75 times higher (χ2=7,08; P=0,008). There was a major increase in representation of both diseases in towns and on islands, and among population of higher education. The highest increase of representation of ulcerative colitis was found among population with onset of disease 18-30 years old and those who were 61-70 years old. The highest increase of Crohn's disease was among the age group with onset of disease 18-30. The part of those who smoke was 14% among the patients with ulcerative colitis, and 26% among those with Crohn's disease. Positive family history was present among both groups of patients equally. Conclusion. Incidance and prevalence of ulcerative colitis has been higher than in previously published studies in Croatia and they have decreased through years of research. Incidance of Crohn's disease hasn't changed through years of research, while prevalence of ulcerative colitis and Crohn's disease has increased linearly. |
