Antiproliferativna aktivnost vodenog ekstrakta biljke Centaurea ragusina L. na dvije stanične linije raka : završni rad
| Autor: | Krejčir, Kornelija |
|---|---|
| Přispěvatelé: | Radan, Mila |
| Jazyk: | chorvatština |
| Rok vydání: | 2016 |
| Předmět: |
rak dojke(MB-MDA 231)
Compositae antiproliferativnost Centaurea ragusina L antiproliferativity glavočike PRIRODNE ZNANOSTI. Kemija Asteraceae NATURAL SCIENCES. Chemistry knapweed dubrovačka zečina farmakoterapija različak MTT-metoda breast cancer(MB-MDA 231) pharmacotherapy rak prostate(T24) zečina prostate cancer(T24) |
| Popis: | Rak (lat. cancer) je pojam koji se koristi za veliku skupinu bolesti u kojima se abnormalne stanice dijele bez kontrole te imaju sposobnost prodiranja i invazije u druga tkiva. Nakupine abnormalnih stanica mogu tvoriti benigne ili maligne tumore. Razlika između njih je u agresivnosti rasta te u tome što maligni daju metastaze i šire se u okolinu, prodirući u okolno tkivo, dok benigni tumori ne daju metastaze na druge organe i ne prodiru u okolno zdravo tkivo, već ga potiskuju odnosno rastu ekspanzivno. Fitoterapeutici ili fitofarmaceutici kao aktivne sastojke sadrže biljke, biljne dijelove i njihove pripravke, a podrazumijevaju standardizirane biljne lijekove sa strogo definiranim sadržajem i sastavom terapijski aktivnih tvari, čija je učinkovitost potvrđena farmakološkim i kliničkim istraživanjima, uz naznaku mogućih nuspojava i interakcija s drugim lijekovima. Cilj ovog rada bio je ispitati antiproliferativno djelovanje vodenih ekstrakta endemske vrste Centaurea ragusina L., koja raste na području Dalmacije, na stanice raka dojke (MB-MDA 231) i raka prostate (T24). Vodeni ekstrakt Centaurea ragusina L. pokazao je dobro antiproliferativno djelovanje na stanice raka prostate i raka dojke. Cancer (lat. cancer) is the term used for a large group of diseases in which abnormal cells divide without control and are capable of penetrating and invading other tissues. Clusters of abnormal cells may form benign or malignant tumors. The difference between them is in the growth aggressivness, and that the malignant tumors can spread and metastasize, penetrating into the surrounding tissue, while benign tumors do not give metastases to other organs and do not invade the surrounding healthy tissue, they grow expansively. Phytotherapeutics or phytopharmaceuticals consist of: plants, plant parts and their extracts, and include standardized herbal drugs with strictly defined content and a composition of a therapeutically active substance. Their effectiveness has been confirmed by pharmacological and clinical research, with the indication of possible side effects and drug interactions. The aim of this study was to examine the antiproliferative activity of aqueous extract of several species of Centaurea ragusina L., which can be found in Dalmatia, on breast cancer cells (MDA-MB 231) and prostate cancer (T24). The aqueous extract of Centaurea ragusina L. showed the best anti-proliferative effect on prostate cancer cells and breast cancer cells. |
| Databáze: | OpenAIRE |
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