| Autor: |
LEONCINI, EMANUELA, PRATA, CECILIA, MALAGUTI, MARCO, MAROTTI, ILARIA, CATIZONE, PIETRO, DINELLI, GIOVANNI, HRELIA, SILVANA, Segura Carretero A. |
| Přispěvatelé: |
SOCIETÀ ITALIANA DI BIOCHIMICA E BIOLOGIA MOLECOLARE, Leoncini E., Prata C., Malaguti M., Marotti I., Segura Carretero A., Catizone P., Dinelli G., Hrelia S. |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
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| Popis: |
Epidemiological studies correlated whole grains intake to a reduced incidence of chronic disease such as cardiovascular disease and cancer. This potentially protective effect could be attributed in part to phenolic compounds present in whole grains and to their strong antioxidant properties. Aim of this study was to characterize the phenolic profile of 6 common wheat genotypes (1 modern and 5 old cultivars) and to evaluate their potential antiproliferative and cytoprotective effect in different cell culture systems. A leukemic cell line, HL60, and cultured rat cardiomyocytes, were supplemented with different phenolic extracts for 24 h and oxidative stress was induced by H2O2-treatment. Antiproliferative and cytoprotective effects were measured in terms of intracellular ROS level decrease and influence on cell viability. Old varieties displayed higher polyphenol and flavonoid content which positively correlated (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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