| Autor: |
PICCINNI, CARLO, SUZZI, CATERINA, POLUZZI, ELISABETTA, SACRIPANTI, CHIARA, BUCCELLATO, ELENA, VACCHERI, ALBERTO, Puccini A., Lapi F., Mazzaglia G. |
| Přispěvatelé: |
Piccinni C., Puccini A., Suzzi C., Poluzzi E., Sacripanti C., Buccellato E., Lapi F., Mazzaglia G., Vaccheri A. |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Popis: |
Background. In clinical trials, adherence with oral anti-osteoporotic therapies is generally high, in contrast with the clinical practice post-authorization. Poor adherence to oral bisphosphonates leads to reduced medication efficacy, exposure to unjustified adverse reactions and raised the health expenditure. Reasons for non-adherent behaviour could include: difficulty taking medication as prescribed, experience of adverse effect and worry of long term harm, scepticism of drug effectiveness and poor perception of the disease consequences (Silverman et al. 2011). The objectives of this study were to quantify the proportion of non-adherent subjects and to define predictors of non-adherence with bisphosphonates in order to develop possible interventions to improve compliance. Methods. A retrospective cohort study has been conducted using administrative database of 13 units joined in the Italian BEST (Bisphosphonate Effectiveness Safety Trade-off) study, accounting for 18 million inhabitants. Patients with at least 2 prescriptions of oral bisphosphonates through 2003–2007 were selected. Exclusion criteria were age |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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