| Autor: |
CANISTRO, DONATELLA, PEROCCO, PAOLO, BARILLARI, JESSICA, VALGIMIGLI, LUCA, PEDULLI, GIAN FRANCO, SAPONE, ANDREA, BROCCOLI, MASSIMILIANO, STRADIOTTI, ALESSANDRO, BIAGI, GIAN LUIGI, PAOLINI, MORENO, R. IORI, V. SBLENDORIO |
| Přispěvatelé: |
D. CANISTRO, P. PEROCCO, J. BARILLARI, R. IORI, L. VALGIMIGLI, G.F. PEDULLI, A. SAPONE, M. BROCCOLI, V. SBLENDORIO, A. STRADIOTTI, G.L. BIAGI, M. PAOLINI |
| Jazyk: |
angličtina |
| Rok vydání: |
2005 |
| Popis: |
Epidemiological and animal studies linking high and varied fruit and vegetable intake to lower cancer risk, suggest the theoretical possibility that regular, long-term mass administration of isolated naturally occurring dietary constituents can provide a means of controlling cancer incidence. Although no exact mechanism of molecular chemoprotection is known, it is believed that the up-regulation of phase-II metabolizing enzymes by phytoalexins, such as sulforaphane - released from its thioglucoside natural precursor, glucoraphanin, by myrosinase hydrolysis – an isothiocyanate found in Cruciferae, could provide a defence against carcinogens.With the aim to verify such hypothesis, the effects of glucoraphanin supplementation on xenobiotic metabolizing enzymes were thus investigated in male and female Sprague-Dawley rats (aged 6-7 weeks, 150±15 g) receiving per os daily either 24 or 48 mg/kg b.w. glucoraphanin and, for comparison, either 120 or 240 mg/kg b.w. of the palmizio cauliflower extract (PCE – OD74 containing the same amount of glucoraphanin) for four consecutive days; controls received saline only and liver microsomes tested for various CYPs.Glucoraphanin slightly affected phase-II “detoxifying” enzymes, but powerfully induced phase-I bioactivating enzymes (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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