| Autor: |
Cingolani A., Zanotti V., Zacchini S., Massi M., Simpson P. V., Maheshkumar Desai N., Casari I., Falasca M., Rigamonti L., Mazzoni R. |
| Přispěvatelé: |
Cingolani A., Zanotti V., Zacchini S., Massi M., Simpson P.V., Maheshkumar Desai N., Casari I., Falasca M., Rigamonti L., Mazzoni R. |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Popis: |
Neutral and cationic cyclopentadienone (CpO) N-heterocyclic carbene (NHC) bis-carbonyl iron(0) complexes bearing, appended to the NHC ligand, either a terminal amino group on the lateral chain, [Fe(η 4 -CpO)(CO) 2 (κC-NHC(CH 2 ) n NH 2 )] with n=2 (2a) and 3 (2b), or a cationic NMe 3+ fragment, [Fe(η 4 -CpO)(CO) 2 (κC-NHC(CH 2 ) 2 NMe 3 )](I) (3), were prepared and characterized in terms of their structure, stability and reactivity. The photochemical properties of 2a and 2b were examined both in organic solvents and in water, revealing the photoactivated release of one CO ligand followed by the formation of the chelated complex [Fe(η 4 -CpO)(CO)(κ 2 C,N-NHC(CH 2 ) 2 NH 2 )] (4), whose molecular structure was confirmed by single crystal X-ray diffraction studies. This metallacyclization occurs only in the case of 2a, with the ethylene spacer between NHC ring and NH 2 group in the lateral chain, allowing the formation of a stable 6-membered ring. On the other hand, 2b undergoes decomposition upon irradiation. The reactivity in aqueous solutions revealed the chemical speciation of the complexes at different pH and especially under physiological conditions (phosphate buffer solution at pH7.4 and 37°C). The lack of data on the biological properties of iron(0) complexes prompted us to preliminarily investigate their cytotoxicity against model cancer cells (AsPC-1 and HPAF-II), along with a determination of their lipophilicity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
