Highly Stereoselective Reduction of β-Keto Amides. The First General and Efficient Approach to N-Mono- and Non-Substituted anti-α-Alkyl β-Hydroxy Amides

Autor: BARTOLI, GIUSEPPE, BOSCO, MARCELLA, MELCHIORRE, PAOLO, RINALDI, SAMUELE, SAMBRI, LETIZIA, E. Marcantoni
Přispěvatelé: G. Bartoli, M. Bosco, E. Marcantoni, P. Melchiorre, S. Rinaldi, L. Sambri
Jazyk: angličtina
Rok vydání: 2004
Předmět:
Popis: The first general protocol for the anti-selective reduction of α-alkyl-b-keto amides is described. This simple and efficient methodology based on an open-chain Felkin-Anh model pathway, allows the isolation of N-mono- and non-substituted anti-a-substituted b-hydroxy amides in good yields and with high diastereoselectivity.
Databáze: OpenAIRE