| Autor: |
DALL'OLIO, FABIO, CHIRICOLO, MARIELLA, MALAGOLINI, NADIA, Caretti A., Trinchera M. |
| Přispěvatelé: |
Dall'Olio F., Chiricolo M., Malagolini N., Caretti A., Trinchera M. |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
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| Popis: |
Sialyl Lewis x (sLex) is a well known selectin ligand involved in metastasis. The molecular bases of its overexpression in colon cancer are still unclear. Here we show that FucT-VI is the main fucosyltransferase responsible for sLex biosynthesis in colonic tissues and a major regulator of sLex expression in colon cancer because: 1) in colon cancer specimens and cell lines sLex expression correlates with the activity of a fucosyltransferase able to fucosylate 3’ sialyllactosamine (3’SLN) at a low (0.5 mM) acceptor concentration. 2) In cells transiently transfected with FucT genes only FucT-VI displays this property. 3) In normal and cancer colon, FucT-VI transcript shows the highest level of expression (about 200 fg/pg actin, vs. 30 for FucT-III, 10 for FucT-IV |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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