| Autor: |
Brion, A. (Anaïs), Chaud, J. (Juliane), Klimezak, M. (Maxime), Bolze, F. (Frédéric), Ohlmann, L. (Laura), Leonard, J. (Jérémie), Chassaing, S. (Stefan), Frisch, B. (Benoît), Kichler, A. (Antoine), Heurtault, B. (Béatrice), Specht, A. (Alexandre) |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| DOI: |
10.1021/acs.bioconjchem.3c00197 |
| Popis: |
Liposome-based nanoparticles able to release, via a photolytic reaction, a payload anchored at the surface of the phospholipid bilayer were prepared. The liposome formulation strategy uses an original drug-conjugated blue light-sensitive photoactivatable coumarinyl linker. This is based on an efficient blue light-sensitive photolabile protecting group modified by a lipid anchor, which enables its incorporation into liposomes, leading to blue to green light-sensitive nanoparticles. In addition, the formulated liposomes were doped with triplet–triplet annihilation upconverting organic chromophores (red to blue light) in order to prepare red light sensitive liposomes able to release a payload, by upconversion-assisted photolysis. Those light-activatable liposomes were used to demonstrate that direct blue or green light photolysis or red light TTA-UC-assisted drug photolysis can effectively photorelease a drug payload (Melphalan) and kill tumor cells in vitro after photoactivation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
