| Autor: |
APICELLA, Antonio, CAPPELLO B, DELNOBILE MA, LAROTONDA MI, MENSITIERI G, NICOLAIS L, SECCIA S. |
| Přispěvatelé: |
Apicella, Antonio, Cappello, B, Delnobile, Ma, Larotonda, Mi, Mensitieri, G, Nicolais, L, Seccia, S. |
| Jazyk: |
angličtina |
| Rok vydání: |
1994 |
| Předmět: |
|
| Popis: |
The release kinetics of monolithic drug delivery devices based on poly(ethylene oxide) (PEG) was investigated. Water soluble PEG's with molecular weights of 600,000 and 4,000,000 and two blends were studied. The water-swelling and dissolution characteristics of the two polymers and two blends, along with the diffusivity of the drug etofylline in the water-penetrated polymer gels were analyzed. The higher molecular weight PEO and the two blends underwent swelling rather than polymer dissolution. As a result, a non-constant release induced by the prevailing diffusive control was observed. Conversely, the drug release from the lower molecular weight PEO was a result of equal rates of swelling and dissolution, which gave a constant release rate. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
