| Autor: |
BALESTRIERI, Maria Luisa, SERVILLO, Luigi, DE PRISCO R., NICOLAUS B., PARI P., SCHIANO MORIELLO V., STRAZZULLO G., IORIO E., BALESTRIERI C. |
| Přispěvatelé: |
Balestrieri, Maria Luisa, DE PRISCO, R., Nicolaus, B., Pari, P., SCHIANO MORIELLO, V., Strazzullo, G., Iorio, E., Servillo, Luigi, Balestrieri, C. |
| Jazyk: |
angličtina |
| Rok vydání: |
2004 |
| Předmět: |
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| Popis: |
Lipophilic compounds contained in tomato can prevent cardiovascular diseases by modulating the atherogenic processes in vascular endothelium mediated by oxidized low-density lipoproteins (LDLs). We investigated the effects of lycopene on the metabolism of platelet-activating factor (PAF) and its much less biologically active acyl analog, acyl-PAF, known to prevent LDL oxidation. Lycopene, or lycopene in association with alpha-tocopherol, or whole tomato lipophilic extracts (containing more than 80% lycopene) were used in experiments in which endothelial cells (ECs) are known to synthesize PAF following H2O2-induced oxidative stress. The results indicated that in each case H2O2-stimulated PAF biosynthesis in ECs, which is catalyzed by acetyl-CoA acetyltransferase (AT), appeared strongly inhibited. However, acyl-PAF biosynthesis, which also occurs through the PAF-dependent transacetylase (TA), was significantly increased by lycopene only when it was in association with a-tocopherol or with the minor compounds present in the whole lipophilic tomato extract. These findings suggest that alpha-tocopherol or lipophilic compounds present in tomato juice potentiate the effects of lycopene on the modulation of PAF and acyl-PAF biosynthesis in ECs during oxidative stress. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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