Pneumococcal serotypes and antibiotic resistance in healthy carriage children after introduction of PCV13 in Lima, Peru

Autor: Gonzales Jaimes, Brayan Enrique, Mercado Zarate, Erik Hernan, Castillo Tokumori, Franco, Montero Quiñe, Andrea Estefania, Luna Muschi, Alessandra Joanna, Marcelo Ragas, Madhelli Natividad, Campos, Francisco, Chaparro Dammert, Luis Eduardo, Del Águila, Olguita, Castillo Díaz, María Esther, Saenz, Andrés, Reyes, Isabel, Hernandez, Roger, Ochoa Woodell, Theresa Jean
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Popis: OBJECTIVE: To determinate the frequency of Streptococcus pneumoniae nasopharyngeal carriers, serotypes and antimicrobial resistance in healthy children in Lima, Peru, post-PCV13 introduction and to compare the results with a similar study conducted between 2006 and 2008 before PCV7 introduction (pre-PCV7). METHODS: A cross-sectional multicenter study was conducted between January 2018 and August 2019 in 1000 healthy children under two years of age. We use standard microbiological methods to determinate S. pneumoniae from nasopharyngeal swab, Kirby Bauer and minimum inhibitory concentration methods to determinate antimicrobial susceptibility and whole genomic sequencing to determinate pneumococcal serotypes. RESULTS: The pneumococcal carriage rate was 20.8 % vs. 31.1 % in pre-PCV7 (p
Databáze: OpenAIRE