| Autor: |
Tzikas, Apostolos p, Shakir, Samera, Sievert, Horst, Omran, Heyder, Berti, Sergio, Santoro, Gennaro, Kefer, Joelle, Landmesser, Ulf, Nielsen-Kudsk, Jens Erik, Cruz-Gonzalez, Ignacio, Danna, Paolo L., Gafoor, Sameer, Tichelbaecker, Tobias, Nietlispach, Fabian, Aminian, Adel, Kasch, Friederike, Freixa, Xavier, Rezzaghi, Marco, Vermeersch, Paul, Stolcova, Miroslava, Schillinger, Wolfgang, Meier, Bernhard, Park, Jai-Wun |
| Přispěvatelé: |
Cardiology, Clinical sciences, Cardio-vascular diseases |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Popis: |
Background: To investigate the safety and efficacy of left atrial appendage occlusion (LAAO) with the Amplatzer Cardiac Plug (ACP) for stroke prevention in patients with atrial fibrillation (AF). Methods: Data from consecutive patients treated in 22 centers were collected. Patients who underwent successful single LAAO and who were on aspirin monotherapy or no therapy at last follow-up were included in the study. Results: A total of 627 patients (age 758 years) fulfilled the inclusion criteria. Of those, 579 were on aspirin (92%) and 48 received no treatment (8%) at last follow-up. The mean CHA2DS2-VASc score was 4.41.5 (annual risk of thromboembolism ¼ 5.62.7%), and the mean HASB-LED Score was 3.21.2 (annual risk of major bleeding ¼ 5.73.9%). There were 3 strokes (0.5%), 1 transient ischemic attack (TIA) (0.2%), and 8 major bleedings (1.3%) in the periprocedural period. The median (IQR) follow-up was 16.2 (9.7-26.2) months, accumulating 981 patient years. A total of 21 deaths were reported during follow-up,which were not reported as device related. There were 3 strokes (0.5%), 6 TIAs (1.0%), and 5 major bleedings (0.8%) during follow-up. The annual rate of systemic thromboembolism was 1.33% (13/981 patient-years), which is a 76.4% risk reduction compared to the annual predicted rate. The annual rate of major bleeding was 1.33% (13/981 patient-years), which is a 76.5% risk reduction. Conclusions: In this multicenter study, LAAO with the ACP and aspirin or no therapy at follow-up was effective in preventing thromboembolism, and was combined with a reduction of major bleeding events. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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