Synthesis of 3-substituted 2-azaanthraquinones and 1,3-disubstituted 2-azaanthraquinones using the Larock isoquinoline synthesis and a protonucleophile-induced ring closing procedure

Autor:	Van Aeken, Sam, Abbaspour Tehrani, Kourosch
Přispěvatelé:	Department of Bio-engineering Sciences, Organic Chemistry
Jazyk:	angličtina
Rok vydání:	2008
Předmět:	Sonogashira coupling napthalene 2-azaanthraquinone
Popis:	2-Azaanthraquinones are well known for their cytotoxicity and are an important topic in cancer research. The synthestic route presented is based upon a Lewis acid catalyzed or protonucleophile induced ring closure starting from o-(1-alkynyl)napthaldehydes. This approach allows the specific incorporation of substituents on postion 1 and 3 of the isoquinoline ring by variation of the alkyne moiety and the protonucleophile.
Databáze:	OpenAIRE
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