| Autor: |
Argacha, Jean-François, Vandeloo, Bert, Van Loo, Ines, Michiels, Vincent, Plein, Daniele, Compte, Nathalie, Lieten, Siddhartha, Cosyns, Bernard |
| Přispěvatelé: |
Clinical sciences, Cardio-vascular diseases, Cardiology, Cardiac Surgery, Heartrhythmmanagement, Gerontology, Geriatrics, Frailty in Ageing, Faculty of Medicine and Pharmacy |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Popis: |
Background/Introduction: Frailty is a syndrome of decreased reserves that leads to adverse outcome after an acute stress. Purpose: The aim of our study was to examine the association between patient frailty and 2 years mortality or lack of dyspnea improvement after transcatheter aortic valve replacement (TAVR). The prognostic effect of nutrition, cognition, mobility and depression was also examined. Methods: Outcomes of 102 TAVR patients performed between March 2015 and January 2020 in a Belgian tertiary center were retrospectively analyzed. Kaplan-Meier and cox proportional hazard model assessed the overall survival function, whereas prognostic factors of 2-year mortality or lack of dyspnea improvement were determined by logistic regression models Results: Mean patient age was 84.2 ± 4.3 years and 75% patients were classified as frail according to Comprehensive Geriatric Assessment Frailty Index (CGA-FI)> 0.1. The 2-year mortality rate after TAVR was 29.4%. There was no significant effect of a CGA-FI >0.1 on2- year mortality and survival time. A geriatric depression scale 5 was a strong and independent predictor of 2-year mortality after TAVR (adjusted OR 10.29, 95% CI: 1.57–67.37, p < 0.05). Similarly, malnutrition status was associated with an increased 2-year mortality after TAVR (adjusted OR 9.10, 95% CI: 1.18–70.25, p < 0.05). There was no association of CGA-FI and geriatric profile with 2-year lack of dyspnea improvement. Conclusions: A CGA-FI >0.1 was not associated with 2 years patient mortality after TAVR. However, a geriatric depression scale 5 and malnutrition appear to be strong and independent predictors of survival after a TAVR procedure |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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