| Autor: |
Herviou, Laurie, Izard, Fanny, De Bruyne, Elke, De Smedt, Eva, Ma, Anqi, Jin, Jian, Vanderkerken, Karin, Julien, Eric, Moreaux, Jerome |
| Přispěvatelé: |
Faculty of Medicine and Pharmacy, Basic (bio-) Medical Sciences, Hematology |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Popis: |
Epigenetic regulation mechanisms - such as histone marks, DNA methylation and miRNA - are often misregulated in cancers and are associated with tumorigenesis and drug resistance. Multiple Myeloma (MM) is a malignant plasma cell disease that accumulates within the bone marrow. Epigenetic modifications in MM are associated not only with cancer development and progression, but also with resistance to chemotherapy. This epigenetic plasticity can be targeted with epidrugs, nowadays used in treatment of several cancers. We recently identified a significant overexpression of the lysine histone methyltransferase SETD8 in MM cells (HMCLs; N=40) compared with normal plasma cells (N=5) (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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