The genetic profile of RF-positive polyarticular juvenile idiopathic arthritis (JIA) resembles adult rheumatoid arthritis (RA)
| Autor: | Hinks, Anne, Marion, Miranda C., Cobb, Joanna, Comeau, Mary E., Sudman, Marc, Ainsworth, Hannah C, Bowes, John, Becker, Mara L, Bohnsack, John F., Haas, Johannes-Peter, Lovell, Daniel J, Mellins, Elizabeth D, Nelson, J. Lee, Nordal, Ellen, Punaro, Marilynn, Reed, Ann M., Rosé, Carlos D., Rosenberg, Alan M, Rygg, Marite, Smith, Samantha L, Stevens, Anne M, Videm, Vibeke, Wallace, Carol A., Wedderburn, Lucy R, Yarwood, Annie, Yeung, Rae S M, Langefeld, Carl D., Thompson, Susan D., Thomson, Wendy, Prahalad, Sampath |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Hinks, A, Marion, M C, Cobb, J, Comeau, M E, Sudman, M, Ainsworth, H C, Bowes, J, Becker, M L, Bohnsack, J F, Haas, J-P, Lovell, D J, Mellins, E D, Nelson, J L, Nordal, E, Punaro, M, Reed, A M, Rosé, C D, Rosenberg, A M, Rygg, M, Smith, S L, Stevens, A M, Videm, V, Wallace, C A, Wedderburn, L R, Yarwood, A, Yeung, R S M, Langefeld, C D, Thompson, S D, Thomson, W & Prahalad, S 2018, ' The genetic profile of RF-positive polyarticular juvenile idiopathic arthritis (JIA) resembles adult rheumatoid arthritis (RA). ', Arthritis and Rheumatology, vol. 70, no. 6, pp. 957-962 . https://doi.org/10.1002/art.40443 |
| Popis: | Objective: Juvenile idiopathic arthritis (JIA) is comprised of seven heterogeneous categories of chronic childhood arthritides. About 5% of children with JIA have rheumatoid factor (RF) positive arthritis, which phenotypically resembles adult rheumatoid arthritis (RA). Our objective was to compare and contrast the genetics of RF-positive polyarticular JIA with RA, and selected other JIA categories, to more fully understand the pathophysiological relationships of inflammatory arthropathies. Methods: RF-positive polyarticular JIA cases (n=340) and controls (n=14,412) were genotyped using the Immunochip array. Single nucleotide polymorphisms (SNPs) were tested for association using a logistic regression model adjusting for admixture proportions. Weighted genetic risk scores (wGRS) of published RA and JIA risk loci were calculated and their ability to predict RF-positive polyarticular JIA were compared. Results: As expected, the HLA region was strongly associated with RF-positive polyarticular JIA (p=5.51x10-31). Nineteen of 44 RA risk loci and 6 of 27 oligoarticular/RF-negative polyarticular JIA risk loci were associated (p70 years. Conclusions: RF-positive polyarticular JIA is genetically more similar to adult RA than to the most common JIA categories and thus appears to be a childhood-onset presentation of autoantibody positive RA. These findings suggest common disease mechanisms, which could lead to novel therapeutic targets and shared treatment strategies. |
| Databáze: | OpenAIRE |
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