| Autor: |
Hughes, M, Moore, T, Manning, J, Wilkinson, J, Watson, S, Samraj, P, Dinsdale, G, Roberts, C, Rhodes, Le, Herrick, Al, Murray, A |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Hughes, M, Moore, T, Manning, J, Wilkinson, J, Watson, S, Samraj, P, Dinsdale, G, Roberts, C, Rhodes, L, Herrick, A & Murray, A 2019, ' A Feasibility Study of a Novel Low Level Light Therapy for Digital Ulcers in Systemic Sclerosis ', Journal of Dermatological Treatment, pp. 1-30 . https://doi.org/10.1080/09546634.2018.1484875 |
| Popis: |
Background: Locally acting, well-tolerated treatments for systemic sclerosis (SSc) digital ulcers (DUs) are needed. Objectives: Our primary aim was to investigate the safety, feasibility and tolerability of a novel low level light therapy (LTTT). A secondary aim was to tentatively assess efficacy. Methods: A custom-built device comprising infrared (850nm), red (660nm) and violet (405nm) LEDs was utilised. DUs were irradiated with 10J/cm2 twice weekly for three weeks, with follow-up at weeks 4&8. Any safety concerns were documented. Patient opinion on time to deliver, feasibility and pain visual analogue score (0-100,100 most severe) was collected. Patient and clinician DU global assessment VAS were documented. DUs were evaluated by laser Doppler perfusion imaging pre- and post-irradiation. Results: 14 DUs in 8 patients received a total of 46 light exposures, with no safety concerns. All patients considered LTTT ‘took just the right amount of time’ and was ‘feasible’, with a low associated mean pain VAS of 1.6 (SD 5.2). Patient and clinician global digital ulcer VAS improved during the study (mean change -7.1 and -5.2, respectively, both P= |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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