Possible treatment and strategies for COVID-19:review and assessment

Autor: Trivedi, N, Verma, A, Kumar, D
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Amides/therapeutic use
Ritonavir/therapeutic use
Anti-Inflammatory Agents/therapeutic use
COVID-19/drug therapy
Adenosine Monophosphate/analogs & derivatives
Complement Inactivating Agents/therapeutic use
Tetracyclines/therapeutic use
Antibodies
Neutralizing/therapeutic use
Cannabinoids/therapeutic use
Humans
Lopinavir/therapeutic use
Antiviral Agents/therapeutic use
Interferons/therapeutic use
Enzyme Inhibitors/therapeutic use
SARS-CoV-2
Immunization
Passive
Alanine/analogs & derivatives
Dexamethasone/therapeutic use
Pyrazines/therapeutic use
Anti-Bacterial Agents/therapeutic use
Drug Combinations
Antibodies
Monoclonal
Humanized/therapeutic use
Hydroxychloroquine/therapeutic use
Thiazoles/therapeutic use
Chloroquine/therapeutic use
Teicoplanin/therapeutic use
COVID-19 Vaccines/therapeutic use
Antiparasitic Agents/therapeutic use
Indoles/therapeutic use
Ivermectin/therapeutic use
Zdroj: Trivedi, N, Verma, A & Kumar, D 2020, ' Possible treatment and strategies for COVID-19 : review and assessment ', European review for medical and pharmacological sciences, vol. 24, no. 23, pp. 12593-12608 . https://doi.org/10.26355/eurrev_202012_24057
DOI: 10.26355/eurrev_202012_24057
Popis: The coronavirus disease 2019 (COVID-19) is declared as an international emergency in 2020. Its prevalence and fatality rate are rapidly increasing but the medication options are still limited for this perilous disease. The emergent outbreak of COVID-19 triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) keeps propagating globally. The present scenario has emphasized the requirement for therapeutic opportunities to relive and overcome this latest pandemic. Despite the fact, the deteriorating developments of COVID-19, there is no drug certified to have considerable effects in the medical treatment for COVID-19 patients. The COVID-19 pandemic requests for the rapid testing of new treatment approaches. Based on the evidence, hydroxychloroquine is the first medicine opted for the treatment of disease. Umifenovir, remdesivir, and fevipiravir are deemed the most hopeful antiviral agent by improving the health of infected patients. The dexamethasone is a first known steroid medicine that can save the lives of seriously ill patients, and it is shown in a randomized clinical trial by the United Kingdom that it reduced the death rate in COVID-19 patients. The current review recapitulates the existing evidence of possible therapeutic drugs, peptides, humanized antibodies, convulsant plasma, and vaccination that has revealed potential in fighting COVID-19 infections. Many randomized and controlled clinical trials are taking place to further validate these agent's safety and effectiveness in curing COVID-19.
Databáze: OpenAIRE
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