| Autor: |
Stakheyeva, Marina N., Patysheva, Marina R., Kaigorodova, Evgeniya V., Zavyalova, Marina V., Tarabanovskaya, Natalia A., Choynzonov, Evgeny L. 1952, Cherdyntseva, Nadezhda V. |
| Jazyk: |
ruština |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Cancer investigation. 2022. Vol. 40, № 5. P. 442-456 |
| Popis: |
In cancer patients, circulating monocytes show functional alterations. Since monocytes are precursors of tumor-associated macrophages (TAMs), TAMs ensuring tumor viability are potentially replenished through the recruitment of monocytes with specific properties. We demonstrated that locoregional metastasis and circulating factors, such as CD45-EpCAM + CD44 + CD24-/low circulating tumor cells, and serum MCP-1 and HMGB1 were statistically associated with modulation of the monocyte features in breast cancer patients. The count of circulating CD45-EpCAM + cells correlated with CD68+, CD163 + monocyte in blood, and with density of CD68 + TAM in breast cancer tumors. Overall, the relationship between monocytes and TAMs is mediated by the tumor in breast cancer patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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